3D radiotherapy in the parotid gland and its dosimetric relationship with salivary flow and quality of life in patients with head and neck cancer

Aim: Hyposalivation and dry mouth affect the quality of life in patients with Head and Neck Cancer, who did the treatment with radiotherapy. Thus this study has the objective to evaluate the dosimetric relationship between 3D radiotherapy and changes in salivary flow, xerostomia and quality of life in patients with head and neck cancer according to the volume of the irradiated parotid gland. Methods: 23 patients with cancer in the head and neck area and in need of 3D radiotherapy were followed up during radiotherapy treatment, and the parotid gland (PG) design was also performed in radiotherapy planning. Questionnaires were carried out to determine xerostomia and quality of life, while the salivary flow was determined through calculations regarding the collection and weighing of saliva. Such data were collected in three moments: before the beginning of the radiotherapy treatment (D0), in the middle of the treatment (D1) and at the end of it (D2). The numerical variables are represented by measures of central tendency and measures of dispersion. Results: when associating the salivary flow, the xerostomia questionnaire and the OHIP-14, a statistically significant difference was found (p-value <0.001), as well as when comparing some volumes of irradiated PG with the OHIP-14. However, no relationship was found between dosimetric data, xerostomia and hyposalivation. Conclusion: patients undergoing 3D radiotherapy for malignant neoplasms in the head and neck region had decreased salivary flow, increased complaints of dry mouth and decreased quality of life. However, it was not possible to establish a statistically significant correlation between these findings and the volumes of irradiated parotids

Herpesvírus humano: tipos, manifestações orais e tratamento / Human herpes virus: types, oral manifestations and treatment

Os herpes vírus humanos (HHV) fazem parte de uma família -Herpesviridae- e têm como seu hospedeiro, unicamente, o homem. São ubíquos e latentes e, uma vez ocorrida a primo-infeção, permanecem no organismo do indíviduo afetado durante toda a sua vida. O presente trabalho se constitui em uma revisão de literatura com o objetivo de abordar os tipos de HHV e seus tratamentos, com ênfase nas manifestações orais. Os HSV 1 e 2 estão geralmente associados à Gengivoestomatite Herpética Primária, Herpes Labial Recorrente e Herpes Intraoral Recorrente. O HHV-3 provoca a Varicela e, por reinfecção, pode ser a causa do surgimento do Herpes-zóster. O HHV- 4 está diretamente ligado à Mononucleosa Infecciosa, ao Linfoma de Burkitt e ao Carcinoma Nasofaríngeo. O HHV-5 pode levar a má-formações congênitas. O HHV-6 provoca o exantema súbito e está associado à esclerose múltipla, o que demonstra seu forte potencial neuro-invasivo. O HHV-7 correlaciona-se ao vírus da AIDS, uma vez que, para ambos, a molécula CD4 é essencial a fim de funcionar como receptor, e o HHV-8 está estreitamente ligado ao Sarcoma de Kaposi. Nenhuma das terapias usadas para o tratamento representa uma cura para a infecção do vírus, uma vez que elas atuam apenas na sua fase ativa. O conhecimento dos tipos virais, das suas características clínicas e manifestações orais são de suma importância para o correto diagnóstico da doença, para a obtenção de sucesso no tratamento e, consequentemente, para a manutenção da saúde populacional.

The human herpes viruses (HHV) take part of a virus family - Herpesviridae- and these viruses have human as only host. They are ubiquitous and latents, and once the primary infection has occurred, they stay within the host's organism for their entire life. This paper is a review about the human herpes viruses types, their treatments and emphasizes their oral manifestations. The HSV 1 and 2 are usually associated to Primary Herpetic Gingivostomatitis, Recurrent Labial Herpes and Reccurent Intra-Oral Herpes. The HHV-3 causes Varicella, mainly in children, and, by reinfection, can be the cause of the appearance of Herpes-zoster. The HHV-4 is directly linked to Infectious Mononucleosis, Burkitt Lymphoma and Nasopharyngeal Carcinoma. The HHV-5 can lead to congenital malformations. The HHV-6 causes sudden rash and is associated with multiple scleroszis, which shows its strong neuro-invasive potential. The HHV-7 is related to AIDS virus because, for both, the CD4 molecule is essential to act as receiver. The HHV-8 is closely linked to Kaposi's Sarcoma. None of the therapies used as treatment gives a cure to the viral infection, once the drugs only have their effect during the virus active phase. The knowledge of the types of herpes virus, its clinical characteristics and oral manifestations is of paramount importance for the correct diagnosis of the disease to obtain treatment success and, consequently, maintenance of population health.

Manifestações orais e maxilofaciais secundárias à bulimia nervosa: uma revisão sistemática / Oral and maxillofacial manifestations secondary to bulimia nervosa: a systematic review

Introdução: A bulimia nervosa é um tipo de transtorno alimentar (fortemente associado à questão do padrão de beleza corporal contemporâneo) que atinge cerca de 1 a 2% da população, com maior prevalência no gênero feminino, apresentando uma gama de alterações importantes e características que acometem a região oral e maxilofacial.Objetivo: Realizar uma revisão da literatura a cerca das publicações sobre as manifestações bucomaxilofaciais secundárias à bulimia nervosa, demonstrando as alterações mais comuns e alertando o cirurgião-dentista para o diagnóstico precoce da doença. Método: 54 artigos científicos indexados (Medline, Lilacs, Scielo e Ibecs) sobre: bulimia nervosa, odontologia, erosão dentária e saúde bucal, entre 2005 e 2010, sofreram leitura crítica para aquisição de informações contidas de interesse ao estudo. Os artigos poderiam ser de revisão da literatura, relato de caso, série de casos ou pesquisa clínica. Foram excluídos aqueles artigos que não discorreram nem citaram pelo menos uma manifestação maxilofacial secundária a bulimia nervosa. Os resultados foram tabulados e estatisticamente tratados de forma descritiva. Resultados: Com base nos critérios de inclusão e exclusão, 31 artigos que falavam especificamente a cerca das manifestações bucomaxilofaciais secundárias à bulimia nervosa foram selecionados. Pôde-se notar um elevado número de publicações envolvendo revisões de literatura em comparação às pesquisas clínicas. O perfil epidemiológico dos pacientes revelou as mulheres adultas jovens como grupo de risco, associado às mais prevalentes manifestações como: erosão e sensibilidade dental, aumento no índice de cárie, mucosite, queilite e gengivite. Conclusão: As manifestações bucomaxilofaciais secundárias à bulimia nervosa podem acometer em graus variados as estruturas duras e moles desta região anatômica. Dentre todas as alterações, a erosão dental foi a mais prevalente em tecido duro e a mucosite em tecido mole.

Introduction:Bulimia nervosa is an eating disorder (strongly associated with the contemporary beauty standard body) that affects about 1 to 2% of the population, often female and aged younger. This disorder induces several important changes in the oral and maxillofacial region. Objective: To review the literature about the oral and maxillofacial manifestations secondary to bulimia nervosa, showing the most common changes and alerting the dentist to early diagnose. Method: 54 scientific articles indexed (Medline, Lilacs, Scielo and Ibecs) about: bulimia nervosa, dentistry, dental erosion and oral health, between 2005 and 2010, suffered critical analysis to acquire interest information for the study. The articles could be review, case report, case series and clinical research. Those article that didn't cite at least one oral or maxillofacial manifestation secondary to bulimia nervosa were excluded. The results were tabulated and statistically treated descriptively. Results: According to inclusion and exclusion criteria, 31 articles about oral and maxillofacial manifestations secondary to bulimia nervosa were selected, and the most publications were literature review. The epidemiological profile showed that the young adult women are a risk group. Erosion and tooth sensitivity, increase rates caries, mucositis, cheilitis and gingivitis were more prevalent clinical manifestations. Conclusion: Oral and maxillofacial manifestations secondary to bulimia nervosa may involve hard and soft structures of this anatomical region. Of all the changes, the dental erosion was more prevalent in the hard tissue and mucositis was more prevalent in the soft tissue.

Morphological analysis of the enamel organ in rats treated with fluoxetine

Purpose: Previous studies have evaluated the presence of serotonin in the dental epithelia and mesenchyme during odontogenesis, suggesting its participation in tooth development. Materials and methods: Here, we used fluoxetine, a selective serotonin re-uptake inhibitor, at a dose of 10 mg/kg, administered for 20 days during pregnancy in 12 Wistar rats to examine the influence of this drug on the development of the enamel organ of the upper first molars of rat fetuses at 17 days of intra-uterine life (i.u.l.), and at one, five and ten days postpartum. The pregnant rats were anesthetized with xylazine at 10 mg/kg and ketamine at 25 mg/kg. The fetuses were removed and beheaded; their jaws were removed, and the upper jaws were exposed. The tissues were fixed in Bouin's fixative, decalcified in 5 percent nitric acid for 4 - 12 h, conventionally processed for microscopy, and embedded in paraffin. Serial sections of approximately 5 mm were obtained and stained with hematoxylin and eosin, as well as periodic acid-Schiff. Results and conclusion: Morphological analysis showed no structural changes in the experimental group compared to the controls, suggesting that, at the dose used, fluoxetine does not interfere with serotonin-mediated development of the enamel organ or the process of amelogenesis.